Immunological Role of TP53 Somatic Mutation Classification in Human Cancers.

ABSTRACT:

Background

TP53 is a very common tumor suppressor gene and has implicated in various cancers. A systematic immunological analysis of TP53 somatic mutation classification in multiple cancers is still lacking.

Methods

To assess the immunological value of TP53 somatic mutation classification in various cancers, we integrated a series of bioinformatics methods to analyze the role of TP53 gene across the public databases, such as UCSC Xena, Cancer Cell Line Encyclopedia (CCLE), Ensembl, and Genotype-Tissue Expression (GTEx).

Results

The results revealed that the TP53 expression level had significant difference in tumor tissues and normal tissues, and it had a high expression level in most malignant tumors. Moreover, the missense mutation

SUBMITTER: Fang J 

PROVIDER: S-EPMC9940963 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature