Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect.

ABSTRACT: Induced pluripotent stem cells (iPSCs) are a promising resource for allogeneic cartilage transplantation to treat articular cartilage defects that do not heal spontaneously and often progress to debilitating conditions, such as osteoarthritis. However, to the best of our knowledge, allogeneic cartilage transplantation into primate models has never been assessed. Here, we show that allogeneic iPSC-derived cartilage organoids survive and integrate as well as are remodeled as articular cartilage in a primate model of chondral defects in the knee joints. Histological analysis revealed that allogeneic iPSC-derived cartilage organoids in chondral defects elicited no immune reaction and directly contributed to tissue repair for at least four months. iPSC-derived cartilage organoids integrated wit

SUBMITTER: Abe K 

PROVIDER: S-EPMC9941131 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature