Differential proteomic patterns of plasma extracellular vesicles show potential to discriminate β-thalassemia subtypes.

ABSTRACT: The observed specificity of β-thalassemia-subtype phenotypes makes new diagnostic strategies that complement current screening methods necessary to determine each subtype and facilitate therapeutic regimens for different patients. Here, we performed quantitative proteomics of plasma-derived extracellular vesicles (EVs) of β-thalassemia major (TM) patients, β-thalassemia intermedia (TI) patients, and healthy controls to explore subgroup characteristics and potential biomarkers. Plasma quantitative proteomics among the same cohorts were analyzed in parallel to compare the biomarker potential of both specimens. EV proteomics showed significantly more abnormalities in immunity and lipid metabolism in TI and TM, respectively. The differential proteomic patterns of EVs were consistent with but m

SUBMITTER: Li N 

PROVIDER: S-EPMC9941134 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature