Immunogenicity of SARS-CoV-2 mRNA intramuscular vaccination in patients with muscular disorders.

ABSTRACT:

Backgrounds

Little clinical data is available on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with muscular disorders (MDs). The immunogenicity of SARS-CoV-2 vaccines against MDs, in particular, remains unknown. Thus, this study aimed to confirm the immunogenicity and safety of the SARS-CoV-2 vaccine against MDs.

Methods

All participants were vaccinated with two doses of mRNA vaccines (BNT162b2, Pfizer-BioNTech). The serum samples were collected from each patient on the day of second dose of vaccination, and then, consecutively, after one month, three months, and six months. Anti-SARS-CoV-2 IgG levels were determined using the Abbott SARS-CoV-2 IgG II Quant assay.

Results

We evaluated 75 individuals, including 42 patients with MDs and 33 pa

SUBMITTER: Kasai R 

PROVIDER: S-EPMC9941142 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature