Additional improvement in regional myocardial ischemia after intracardiac injection of bone marrow cells during CABG surgery.

ABSTRACT:

Background

Post-procedure residual ischemia is associated with worse prognosis in patients with coronary artery diasease (CAD).

Objective

We evaluated whether autologous bone marrow-derived cells (BMC) contribute to additional reduction in regional stress-induced myocardial ischemia (SIMI) in patients undergoing incomplete coronary artery bypass graft surgery (CABG).

Methods

In a double-blind, randomized, placebo-controlled trial, we enrolled 143 patients (82% men, 58 ± 11 years) with stable CAD and not candidates for complete CABG. They received 100 million BMC (n = 77) or placebo (n = 66) injected into ischemic non-revascularized segments during CABG. The primary outcome was improvement on SIMI quantified as the area at risk in injected segments assess

SUBMITTER: Gowdak LHW 

PROVIDER: S-EPMC9941147 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature