Discovering hematoma-stimulated circuits for secondary brain injury after intraventricular hemorrhage by spatial transcriptome analysis.

ABSTRACT:

Introduction

Central nervous system (CNS) diseases, such as neurodegenerative disorders and brain diseases caused by acute injuries, are important, yet challenging to study due to disease lesion locations and other complexities.

Methods

Utilizing the powerful method of spatial transcriptome analysis together with novel algorithms we developed for the study, we report here for the first time a 3D trajectory map of gene expression changes in the brain following acute neural injury using a mouse model of intraventricular hemorrhage (IVH). IVH is a common and representative complication after various acute brain injuries with severe mortality and mobility implications.

Results

Our data identified three main 3D global pseudospace-time trajectory bundles that represent the

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9941151 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature