Machine learning analysis of complex late gadolinium enhancement patterns to improve risk prediction of major arrhythmic events.

ABSTRACT:

Background

Machine learning analysis of complex myocardial scar patterns affords the potential to enhance risk prediction of life-threatening arrhythmia in stable coronary artery disease (CAD).

Objective

To assess the utility of computational image analysis, alongside a machine learning (ML) approach, to identify scar microstructure features on late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR) that predict major arrhythmic events in patients with CAD.

Methods

Patients with stable CAD were prospectively recruited into a CMR registry. Shape-based scar microstructure features characterizing heterogeneous ('peri-infarct') and homogeneous ('core') fibrosis were extracted. An ensemble of machine learning approaches were used for risk stratification, in

SUBMITTER: Zaidi HA 

PROVIDER: S-EPMC9941157 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature