Serum metabolites associated with wholegrain consumption using nontargeted metabolic profiling: a discovery and reproducibility study.

ABSTRACT:

Purpose

To identify fasting serum metabolites associated with WG intake in a free-living population adjusted for potential confounders.

Methods

We selected fasting serum samples at baseline from a subset (n = 364) of the prospective population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) cohort. The samples were analyzed using nontargeted metabolomics with liquid chromatography coupled with mass spectrometry (LC-MS). Association with WG intake was investigated using both random forest followed by linear regression adjusted for age, BMI, smoking, physical activity, energy and alcohol consumption, and partial Spearman correlation adjusted for the same covariates. Features selected by any of these models were shortlisted for annotation. We then checked if we co

SUBMITTER: Noerman S 

PROVIDER: S-EPMC9941277 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature