Dataset Information

Clinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians.

ABSTRACT:

Objectives

To analyze the clinical characteristics and outcomes of admitted patients with the hospital- versus community-manifested COVID-19 and to evaluate the risk factors related to mortality in the first population.

Methods

This retrospective cohort included consecutive adult patients with COVID-19, hospitalized between March and September 2020. The demographic data, clinical characteristics, and outcomes were extracted from medical records. Patients with hospital-manifested COVID-19 (study group) and those with community-manifested COVID-19 (control group) were matched by the propensity score model. Logistic regression models were used to verify the risk factors for mortality in the study group.

Results

Among 7,710 hospitalized patients who had COVID-19, 7.2% developed symptoms while admitted for other reasons. Patients with hospital-manifested COVID-19 had a higher prevalence of cancer (19.2% vs 10.8%) and alcoholism (8.8% vs 2.8%) than patients with community-manifested COVID-19 and also had a higher rate of intensive care unit requirement (45.1% vs 35.2%), sepsis (23.8% vs 14.5%), and death (35.8% vs 22.5%) (P <0.05 for all). The factors independently associated with increased mortality in the study group were increasing age, male sex, number of comorbidities, and cancer.

Conclusion

Hospital-manifested COVID-19 was associated with increased mortality. Increasing age, male sex, number of comorbidities, and cancer were independent predictors of mortality among those with hospital-manifested COVID-19 disease.

SUBMITTER: Delfino-Pereira P

PROVIDER: S-EPMC9941311 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Clinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians.

Delfino-Pereira Polianna P Pires Magda Carvalho MC Gomes Virginia Mara Reis VMR Nogueira Matheus Carvalho Alves MCA Lima Maria Clara Pontello Barbosa MCPB Schwarzbold Alexandre Vargas AV Maurílio Amanda de Oliveira AO Scotton Ana Luiza Bahia Alves ALBA Costa André Soares de Moura ASM Farace Barbara Lopes BL de Castro Bruno Mateus BM Cimini Christiane Corrêa Rodrigues CCR Silveira Daniel Vitório DV Ponce Daniela D Pereira Elayne Crestani EC Roesch Eliane Würdig EW Manenti Euler Roberto Fernandes ERF Cenci Evelin Paola de Almeida EPA Dos Santos Fernanda Costa FC Anschau Fernando F Aranha Fernando Graça FG Bartolazzi Frederico F Nascimento Guilherme Fagundes GF Vianna Heloisa Reniers HR d'Arc Lyra Batista Joanna J de Alvarenga Joice Coutinho JC Carvalho Juliana da Silva Nogueira JDSN Machado-Rugolo Juliana J Ruschel Karen Brasil KB Menezes Luanna Silva Monteiro LSM de Castro Luís César LC Nasi Luiz Antônio LA Floriani Maiara Anschau MA Souza Maíra Dias MD Souza-Silva Maíra Viana Rego MVR Carneiro Marcelo M Bicalho Maria Aparecida Camargos MAC de Godoy Mariana Frizzo MF Guimarães-Júnior Milton Henriques MH Ziegelmann Patricia Klarmann PK Assaf Pedro Ledic PL Martelli Petrônio José de Lima PJL Finger Renan Goulart RG Francisco Saionara Cristina SC Araújo Silvia Ferreira SF Oliveira Talita Fischer TF de Oliveira Thainara Conceição TC Lage Thalita Martins TM Muller Vanessa V Ramires Yuri Carlotto YC Ferrari Teresa Cristina de Abreu TCA Marcolino Milena Soriano MS

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20230221

<h4>Objectives</h4>To analyze the clinical characteristics and outcomes of admitted patients with the hospital- versus community-manifested COVID-19 and to evaluate the risk factors related to mortality in the first population.<h4>Methods</h4>This retrospective cohort included consecutive adult patients with COVID-19, hospitalized between March and September 2020. The demographic data, clinical characteristics, and outcomes were extracted from medical records. Patients with hospital-manifested C ...[more]

PMID: 36813081

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Project description:BackgroundWe aimed to describe the characteristics and in-hospital outcomes of ST-segment elevation myocardial infarction (STEMI) patients during the Covid-19 era.MethodsWe conducted a prospective, multicenter study involving 13 intensive cardiac care units, to evaluate consecutive STEMI patients admitted throughout an 8-week period during the Covid-19 outbreak. These patients were compared with consecutive STEMI patients admitted during the corresponding period in 2018 who had been prospectively documented in the Israeli bi-annual National Acute Coronary Syndrome Survey. The primary end-point was defined as a composite of malignant arrhythmia, congestive heart failure, and/or in-hospital mortality. Secondary outcomes included individual components of primary outcome, cardiogenic shock, mechanical complications, electrical complications, re-infarction, stroke, and pericarditis.ResultsThe study cohort comprised 1466 consecutive acute MI patients, of whom 774 (53%) were hospitalized during the Covid-19 outbreak. Overall, 841 patients were diagnosed with STEMI: 424 (50.4%) during the Covid-19 era and 417 (49.6%) during the parallel period in 2018. Although STEMI patients admitted during the Covid-19 period had fewer co-morbidities, they presented with a higher Killip class (p value = .03). The median time from symptom onset to reperfusion was extended from 180 minutes (IQR 122-292) in 2018 to 290 minutes (IQR 161-1080, p < .001) in 2020. Hospitalization during the Covid-19 era was independently associated with an increased risk of the combined endpoint in the multivariable regression model (OR 1.65, 95% CI 1.03-2.68, p value = .04). Furthermore, the rate of mechanical complications was four times higher during the Covid-19 era (95% CI 1.42-14.8, p-value = .02). However, in-hospital mortality remained unchanged (OR 1.73, 95% CI 0.81-3.78, p-value = .16).ConclusionsSTEMI patients admitted during the first wave of Covid-19 outbreak, experienced longer total ischemic time, which was translated into a more severe disease status upon hospital admission, and a higher rate of in-hospital adverse events, compared with parallel period.

Dataset Information

Clinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians.

Objectives

Methods

Results

Conclusion

Publications

Clinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians.

Similar Datasets

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