Computational investigation of IP₃ diffusion.

ABSTRACT: Inositol 1,4,5-trisphosphate (IP₃) plays a key role in calcium signaling. After stimulation, it diffuses from the plasma membrane where it is produced to the endoplasmic reticulum where its receptors are localized. Based on in vitro measurements, IP₃ was long thought to be a global messenger characterized by a diffusion coefficient of ~ 280 μm²s^-1. However, in vivo observations revealed that this value does not match with the timing of localized Ca²⁺ increases induced by the confined release of a non-metabolizable IP₃ analog. A theoretical analysis of these data concluded that in intact cells diffusion of IP₃ is strongly hindered, leading to a 30-fold reduction of the diffusion coefficient. Here, we performed a ne

SUBMITTER: Ornelas-Guevara R 

PROVIDER: S-EPMC9941478 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature