Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis.

ABSTRACT:

Aims

Diabetes will lead to serious complications, of which atherosclerosis is the most dangerous. This study aimed to explore the mechanisms of diabetic atherosclerosis.

Methods

ApoE^-/- mice were fed with an high-fat diet diet and injected with streptozotocin to establish an in vivo diabetic atherosclerotic model. RAW 264.7 cells were treated with oxidized low-density lipoprotein particles (ox-LDL) and high glucose to produce an in vitro diabetic atherosclerotic model.

Results

In this study, we showed that diabetes promoted the progression of atherosclerosis in ApoE^-/- mice and that high glucose potentiates macrophage proinflammatory activation and foam cell formation. Mechanistically, Copper metabolism MURR1 domain-containing 1(COM

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9941604 | biostudies-literature | 2023 Jan-Feb

REPOSITORIES: biostudies-literature