Digital expression profile of immune checkpoint genes in medulloblastomas identifies CD24 and CD276 as putative immunotherapy targets.

ABSTRACT:

Introduction

Medulloblastoma is the most common and lethal pediatric malignant brain tumor. It comprises four main molecular subgroups: WNT-activated, SHH-activated, Group 3, and Group 4. Medulloblastoma treatment is surgical resection, craniospinal radiation, and chemotherapy. However, many patients do not respond to therapy, and most suffer severe side effects. Cancer immunotherapy targeting immune checkpoints (IC) (PD-1, PD-L1, and CTLA4) has been getting disappointing outcomes in brain tumors. Nevertheless, other less explored immune checkpoints may be promising candidates for medulloblastoma therapy.

Objectives

In the present study, we aimed to characterize the expression profile of 19 immune checkpoints in medulloblastoma.

Methods

We analyzed 88 formalin-fixed p

SUBMITTER: Marques RF 

PROVIDER: S-EPMC9941636 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature