Embryonic ethanol exposure disrupts craniofacial neuromuscular integration in zebrafish larvae.

ABSTRACT: Forming a vertebrate head involves the meticulous integration of multiple tissue types during development. Prenatal alcohol exposure is known to cause a variety of birth defects, especially to tissues in the vertebrate head. However, a systematic analysis of coordinated defects across tissues in the head is lacking. Here, we delineate the effects of ethanol on individual tissue types and their integration during craniofacial development. We found that exposure to 1% ethanol induced ectopic cranial muscle and nerve defects with only slight effects on skeletal pattern. Ectopic muscles were, however, unaccompanied by ectopic tendons and could be partially rescued by anesthetizing the larvae before muscle fibers appeared. This finding suggests that the ectopic muscles result from fiber detachm

SUBMITTER: Ghosal R 

PROVIDER: S-EPMC9941677 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature