Identification and validation of neurotrophic factor-related gene signatures in glioblastoma and Parkinson's disease.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is the most common cancer of the central nervous system, while Parkinson's disease (PD) is a degenerative neurological condition frequently affecting the elderly. Neurotrophic factors are key factors associated with the progression of degenerative neuropathies and gliomas.

Methods

The 2601 neurotrophic factor-related genes (NFRGs) available in the Genecards portal were analyzed and 12 NFRGs with potential roles in the pathogenesis of Parkinson's disease and the prognosis of GBM were identified. LASSO regression and random forest algorithms were then used to screen the key NFRGs. The correlation of the key NFRGs with immune pathways was verified using GSEA (Gene Set Enrichment Analysis). A prognostic risk scoring system was constructed

SUBMITTER: Zhao S 

PROVIDER: S-EPMC9941742 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature