Insights into autoregulation of a membrane protein complex by its cytoplasmic domains.

ABSTRACT: Membrane transporters mediate the passage of molecules across membranes and are essential for cellular function. While the transmembrane region of these proteins is responsible for substrate transport, often the cytoplasmic regions are required for modulating their activity. However, it can be difficult to obtain atomic-resolution descriptions of these autoregulatory domains by classical structural biology techniques, especially if they lack a single, defined structure. The betaine permease, BetP, a homotrimer, is a prominent and well-studied example of a membrane protein whose autoregulation depends on cytoplasmic N- and C-terminal segments. These domains sense and transduce changes in K⁺ concentration and in lipid bilayer properties caused by osmotic stress. However, structura

SUBMITTER: Leone V 

PROVIDER: S-EPMC9941749 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature