Volume regulation in adhered cells: Roles of surface tension and cell swelling.

ABSTRACT: The volume of adhered cells has been shown experimentally to decrease during spreading. This effect can be understood from the pump-leak model, which we have extended to include mechano-sensitive ion transporters. We identify a novel effect that has important consequences on cellular volume loss: cells that are swollen due to a modulation of ion transport rates are more susceptible to volume loss in response to a tension increase. This effect explains in a plausible manner the discrepancies between three recent, independent experiments on adhered cells, between which both the magnitude of the volume change and its dynamics varied substantially. We suggest that starved and synchronized cells in two of the experiments were in a swollen state and, consequently, exhibited a large volume loss a

SUBMITTER: Adar RM 

PROVIDER: S-EPMC9941750 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature