The effect of repeated remote ischemic postconditioning after an ischemic stroke (REPOST): A randomized controlled trial.

ABSTRACT:

Background and aims

A potential strategy to treat ischemic stroke may be the application of repeated remote ischemic postconditioning (rIPostC). This consists of several cycles of brief periods of limb ischemia followed by reperfusion, which can be applied by inflating a simple blood pressure cuff and subsequently could result in neuroprotection after stroke.

Methods

Adult patients admitted with an ischemic stroke in the past 24 h were randomized 1:1 to repeated rIPostC or sham-conditioning. Repeated rIPostC was performed by inflating a blood pressure cuff around the upper arm (4 × 5 min at 200 mm Hg), which was repeated twice daily during hospitalization with a maximum of 4 days. Primary outcome was infarct size after 4 days or at discharge. Secondary outcomes included the

SUBMITTER: Landman TR 

PROVIDER: S-EPMC9941800 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature