Evaluation of Maternal Infection During Pregnancy and Childhood Leukemia Among Offspring in Denmark.

ABSTRACT:

Importance

Maternal infection is common during pregnancy and is an important potential cause of fetal genetic and immunological abnormalities. Maternal infection has been reported to be associated with childhood leukemia in previous case-control or small cohort studies.

Objective

To evaluate the association of maternal infection during pregnancy with childhood leukemia among offspring in a large study.

Design, setting, and participants

This population-based cohort study used data from 7 Danish national registries (including the Danish Medical Birth Register, the Danish National Patient Registry, the Danish National Cancer Registry, and others) for all live births in Denmark between 1978 and 2015. Swedish registry data for all live births between 1988 and 2014 were use

SUBMITTER: He JR 

PROVIDER: S-EPMC9941888 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature