Intermittent Apomorphine Use for off Period Rescue in Parkinson's Disease: A Pragmatic Review of over Three Decades of Clinical Experience.

ABSTRACT:

Background

Although proven very efficacious as treatment for Parkinson's disease by Schwab as far back as the 1950s, and later confirmed by Cotzias and colleagues in the early 1970s, use of intermittent subcutaneous injections of the dopamine agonist apomorphine remains limited worldwide.

Objectives

To review evidence regarding use of intermittent, on-demand apomorphine as a treatment for off-period disability in Parkinson's disease.

Methods

A PRISMA-compliant structured literature search was carried out with a focus on clinical effect (motor improvement, daily off time decrease; latency, duration), antiemetic prophylaxis, and adverse events.

Results

Fifty-eight studies were evaluated. Apomorphine administration route was subcutaneous in 29 (50%), sublingual in

SUBMITTER: Castillo-Torres SA 

PROVIDER: S-EPMC9941929 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature