Transcriptomic analysis reveals the immune response of human microglia to a soy protein and collagen hybrid bioscaffold.

ABSTRACT: Inflammatory reactions resulting from spinal cord injury cause significant secondary damage. Microglial cells activate CD4⁺ T cells via major histocompatibility complex class II (MHCII) molecules. The activated T cells lead to neural tissue damage and demyelination at early stages of spinal cord injury. Control of the inflammatory response may attenuate the injury process. In this study, we compared gene expression in human microglia grown on soy protein-collagen hybrid scaffolds versus collagen scaffolds. Differentially expressed genes (DEGs) were subjected to gene ontology (GO) and pathway enrichment assays. Among down-regulated genes, the "antigen processing and presentation" pathway shows enrichment, primarily due to the down-regulation of MHCII molecules. The DEGs in this p

SUBMITTER: Yao L 

PROVIDER: S-EPMC9941947 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature