Trends in Postmortem Neurodegenerative and Cerebrovascular Neuropathologies Over 25 Years.

ABSTRACT:

Importance

With rapid aging of the US population, understanding trends over time in dementia occurrence is essential to public health planning and intervention; this understanding includes trends in neuropathologies underlying clinical dementia.

Objective

To characterize trends in pathways underlying dementia by examining prevalence of postmortem neuropathologies in birth cohorts across 25 years.

Design, setting, and participants

Two longitudinal cohorts, the Religious Orders Study and the Rush Memory and Aging Project, with autopsy data from 1997 to 2022 with up to 27 years follow-up were analyzed. Deceased individuals with complete postmortem neuropathology evaluations were included, and 177 individuals with most distant (<1905) or recent (>1930) years of birth were

SUBMITTER: Grodstein F 

PROVIDER: S-EPMC9941972 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature