Development and Application of Whole-Cell Biosensors for the Detection of Gallic Acid.

ABSTRACT: Gallic acid is a prevalent secondary plant metabolite distinguished as one of the most effective free-radical scavengers among phenolic acids. This compound is also known for its cytotoxic, anti-inflammatory, and antimicrobial activities. Bulk quantities of gallic acid are conventionally produced by acid hydrolysis of tannins, a costly and environmentally hazardous process. With the aim to develop more sustainable approaches, microbial bioproduction strategies have been attempted recently. To advance synthetic biology and metabolic engineering of microorganisms for gallic acid production, we characterize here a transcription factor-based inducible system PpGalR/P_{PP_RS13150} that responds to the extracellular gallic acid in a dose-dependent manner in Pseudomonas p

SUBMITTER: Kutraite I 

PROVIDER: S-EPMC9942251 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature