An observational study of dose dense chemotherapy with lipegfilgrastim support in early breast cancer.

ABSTRACT:

Purpose

Breast cancer is one of the most prevalent malignant diseases in women. The development of dose dense chemotherapy regimens has improved clinical outcomes but has been associated with increased hematological toxicity. Currently there is a paucity of data on the use of lipegfilgrastim in dose dense AC treatment in early breast cancer. The purpose of this study was to assess the use of lipegfilgrastim in the treatment of early breast cancer and to examine the incidence of treatment-related neutropenia during the dose dense AC phase and subsequent paclitaxel treatment.

Methods

This was a single arm, non-interventional, prospective study. The primary endpoint was to determine the rate of neutropenia defined as ANC of < 1.0 × 10⁹/L, during four cycles of dose d

SUBMITTER: Rashed A 

PROVIDER: S-EPMC9942277 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature