Monocyte, neutrophil, and whole blood transcriptome dynamics following ischemic stroke.

ABSTRACT:

Background

After ischemic stroke (IS), peripheral leukocytes infiltrate the damaged region and modulate the response to injury. Peripheral blood cells display distinctive gene expression signatures post-IS and these transcriptional programs reflect changes in immune responses to IS. Dissecting the temporal dynamics of gene expression after IS improves our understanding of immune and clotting responses at the molecular and cellular level that are involved in acute brain injury and may assist with time-targeted, cell-specific therapy.

Methods

The transcriptomic profiles from peripheral monocytes, neutrophils, and whole blood from 38 ischemic stroke patients and 18 controls were analyzed with RNA-seq as a function of time and etiology after stroke. Differential expression analy

SUBMITTER: Carmona-Mora P 

PROVIDER: S-EPMC9942321 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature