The interplay of inflammation, exosomes and Ca²⁺ dynamics in diabetic cardiomyopathy.

ABSTRACT: Diabetes mellitus is one of the prime risk factors for cardiovascular complications and is linked with high morbidity and mortality. Diabetic cardiomyopathy (DCM) often manifests as reduced cardiac contractility, myocardial fibrosis, diastolic dysfunction, and chronic heart failure. Inflammation, changes in calcium (Ca²⁺) handling and cardiomyocyte loss are often implicated in the development and progression of DCM. Although the existence of DCM was established nearly four decades ago, the exact mechanisms underlying this disease pathophysiology is constantly evolving. Furthermore, the complex pathophysiology of DCM is linked with exosomes, which has recently shown to facilitate intercellular (cell-to-cell) communication through biomolecules such as micro RNA (miRNA), proteins,

SUBMITTER: Sanganalmath SK 

PROVIDER: S-EPMC9942322 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature