Complement-related molecular classification and a gene signature for lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is a major cause of cancer-related death worldwide, and the roles of complement-related genes in it have not been thoroughly investigated yet. In the study, we aimed to systemically examine the prognostic performance of complement-related genes, classify the patients into two different clusters and stratify the patients into different risk groups using a complement-related gene signature.

Methods

To achieve this, clustering analyses, Kaplan-Meier survival analyses, immune infiltration analyses were performed. LUAD patients from The Cancer Genome Atlas (TCGA) were classified into two subtypes (C1 and C2). A prognostic signature, consisting of four complement-related genes, was established using TCGA-LUAD cohort and validated in six Gene E

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9942347 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature