Icariin-conditioned serum combined with chitosan attenuates cartilage injury in rabbit knees with osteochondral defect.

ABSTRACT:

Background

Knee osteoarthritis (KOA) is one of the most common degenerative diseases. Its development is closely related to cartilage injury and subchondral bone remodeling homeostasis. In the present study, we combined icariin-conditioned serum (ICS) with thiolated chitosan (CSSH), a material widely used in tissue engineering for cartilage repair, to demonstrate its effect on the repair of cartilage damage and abnormal subchondral remodeling.

Methods

New Zealand rabbits were undergoing surgery for cartilage defect, and joint cavity injection was performed in each group with 0.5 mL normal saline (NS), ICS, CSSH and ICS-CSSH in the right joint every week for five times. Positioning performance was observed using VICON motion capture system. Glycosaminoglycans (GAG) secretion

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9942393 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature