Changes of serum IgG glycosylation patterns in rheumatoid arthritis.

ABSTRACT:

Background

RA is a common chronic and systemic autoimmune disease, and the diagnosis is based significantly on autoantibody detection. This study aims to investigate the glycosylation profile of serum IgG in RA patients using high-throughput lectin microarray technology.

Method

Lectin microarray containing 56 lectins was applied to detect and analyze the expression profile of serum IgG glycosylation in 214 RA patients, 150 disease controls (DC), and 100 healthy controls (HC). Significant differential glycan profiles between the groups of RA and DC/HC as well as RA subgroups were explored and verified by lectin blot technique. The prediction models were created to evaluate the feasibility of those candidate biomarkers.

Results

As a comprehensive analysis of lectin micr

SUBMITTER: Deng X 

PROVIDER: S-EPMC9942403 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature