Association between visit-to-visit blood pressure variability and risks of dementia in CKD patients: a nationwide observational cohort study.

ABSTRACT:

Background

The association between visit-to-visit blood pressure (BP) variability and dementia risk in chronic kidney disease (CKD) patients has rarely been studied.

Methods

In this retrospective observational study, individuals who received three or more general health screenings were identified in the nationwide database of Korea. Those with persistent non-dialysis-dependent CKD [estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² or dipstick albuminuria ≥1+] were included. The study exposure was systolic or diastolic BP variability, calculated as the variation independent of the mean and categorized into quartiles (Q4: the highest quartile; Q1: the lowest quartile). The risks of all-cause dementia, including Alzheimer's disease and vascular dementia,

SUBMITTER: Park S 

PROVIDER: S-EPMC9942440 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature