An integrated chance constraints approach for optimal vaccination strategies under uncertainty for COVID-19.

ABSTRACT: Despite concerted efforts by health authorities worldwide to contain COVID-19, the SARS-CoV-2 virus has continued to spread and mutate into new variants with uncertain transmission characteristics. Therefore, there is a need for new data-driven models for determining optimal vaccination strategies that adapt to the new variants with their uncertain transmission characteristics. Motivated by this challenge, we derive an integrated chance constraints stochastic programming (ICC-SP) approach for finding vaccination strategies for epidemics that incorporates population demographics for any region of the world, uncertain disease transmission and vaccine efficacy. An optimal vaccination strategy specifies the proportion of individuals in a given household-type to vaccinate to bring the reproduct

SUBMITTER: Gong J 

PROVIDER: S-EPMC9942454 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature