Investigating the competition between ACE2 natural molecular interactors and SARS-CoV-2 candidate inhibitors.

ABSTRACT: The SARS-CoV-2 pandemic still poses a threat to the global health as the virus continues spreading in most countries. Therefore, the identification of molecules capable of inhibiting the binding between the ACE2 receptor and the SARS-CoV-2 spike protein is of paramount importance. Recently, two DNA aptamers were designed with the aim to inhibit the interaction between the ACE2 receptor and the spike protein of SARS-CoV-2. Indeed, the two molecules interact with the ACE2 receptor in the region around the K353 residue, preventing its binding of the spike protein. If on the one hand this inhibition process hinders the entry of the virus into the host cell, it could lead to a series of side effects, both in physiological and pathological conditions, preventing the correct functioning of the AC

SUBMITTER: Milanetti E 

PROVIDER: S-EPMC9942480 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature