Comparison of anal pre-cancer screening strategies among men who have sex with men.

ABSTRACT:

Purpose

Comparison of anal pre-cancer screening strategies in men who have sex with men (MSM).

Methods

MSM in the Multicenter AIDS Cohort Study underwent repeated anal cytology (aCyt), oncogenic human papillomavirus (oncHPV) testing. A subset received High-Resolution Anoscopy (HRA). We evaluated three screening strategies for their ability to predict anal histological High-Grade Squamous Intraepithelial lesion (HSIL): single aCyt, sequential aCyt, and oncHPV co-testing. Multivariable logistic regression models evaluated risk of HSIL among participants undergoing HRA within 5 years of screening. Sensitivity and specificity were estimated among participants with HRA, and results corrected for verification bias using weighted generalized estimating equations.

Results

The

SUBMITTER: Sun J 

PROVIDER: S-EPMC9942485 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature