Very early environmental enrichment protects against apoptosis and improves functional recovery from hypoxic-ischemic brain injury.

ABSTRACT: Appropriate rehabilitation of stroke patients at a very early phase results in favorable outcomes. However, the optimal strategy for very early rehabilitation is at present unclear due to the limited knowledge on the effects of very early initiation of rehabilitation based on voluntary exercise (VE). Environmental enrichment (EE) is a therapeutic paradigm for laboratory animals that involves complex combinations of physical, cognitive, and social stimuli, as well as VE. Few studies delineated the effect of EE on apoptosis in very early stroke in an experimental model. Although a minimal benefit of early rehabilitation in stroke models has been claimed in previous studies, these were based on a forced exercise paradigm. The aim of this study is to determine whether very early exposure to EE

SUBMITTER: Lee HY 

PROVIDER: S-EPMC9942523 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature