Responses of model cortical neurons to temporal interference stimulation and related transcranial alternating current stimulation modalities.

ABSTRACT: Objective.Temporal interference stimulation (TIS) was proposed as a non-invasive, focal, and steerable deep brain stimulation method. However, the mechanisms underlying experimentally-observed suprathreshold TIS effects are unknown, and prior simulation studies had limitations in the representations of the TIS electric field (E-field) and cerebral neurons. We examined the E-field and neural response characteristics for TIS and related transcranial alternating current stimulation modalities.Approach.Using the uniform-field approximation, we simulated a range of stimulation parameters in biophysically realistic model cortical neurons, including different orientations, frequencies, amplitude ratios, amplitude modulation, and phase difference of the E-fields, and obtained thresho

SUBMITTER: Wang B 

PROVIDER: S-EPMC9942661 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature