Surface Presentation of Hyaluronic Acid Modulates Nanoparticle-Cell Association.

ABSTRACT: Nanoparticle (NP) drug carriers have revolutionized medicine and increased patient quality of life. Clinically approved formulations typically succeed because of reduced off-target toxicity of the cargo. However, increasing carrier accumulation at disease sites through precise targeting remains one of the biggest challenges in the field. Novel multivalent ligand presentations and self-assembled constructs can enhance cell association, but an inability to draw direct comparisons across formulations has hindered progress. Furthermore, how nanoparticle structure influences function often is unclear. In this report, we leverage the well-characterized hyaluronic acid (HA)-CD44 binding pair to investigate how the surface architecture of modified NPs impacts their association with ovarian cancer

SUBMITTER: Deiss-Yehiely E 

PROVIDER: S-EPMC9942780 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature