Nitro-oleic acid regulates T cell activation through post-translational modification of calcineurin.

ABSTRACT: Nitro-fatty acids (NO₂-FAs) are unsaturated fatty acid nitration products that exhibit anti-inflammatory actions in experimental mouse models of autoimmune and allergic diseases. These electrophilic molecules interfere with intracellular signaling pathways by reversible post-translational modification of nucleophilic amino-acid residues. Several regulatory proteins have been identified as targets of NO₂-FAs, modifying their activity and promoting gene expression changes that result in anti-inflammatory effects. Herein, we report the effects of nitro-oleic acid (NO₂-OA) on pro-inflammatory T cell functions, showing that 9- and 10-NOA, but not their oleic acid precursor, decrease T cell proliferation, expression of activation markers CD25 and CD71 on the plas

SUBMITTER: Bago A 

PROVIDER: S-EPMC9942794 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature