Community-based serum chloride abnormalities predict mortality risk.

ABSTRACT:

Introduction

This population-based study aimed to investigate the prognostic value of ambulatory serum chloride abnormalities, often ignored by physicians.

Methods

The study population included all non-hospitalized adult patients, insured by "Clalit" Health Services in Israel's southern district, who underwent at least 3 serum chloride tests in community-based clinics during 2005-2016. For each patient, each period with low (≤97 mmol/l), high (≥107 mmol/l) or normal chloride levels were recorded. A Cox proportional hazards model was used to estimate the mortality risk of hypochloremia and hyperchloremia periods.

Results

664,253 serum chloride tests from 105,655 subjects were analyzed. During a median follow up of 10.8 years, 11,694 patients died. Hypochloremia (≤ 97 m

SUBMITTER: Shafat T 

PROVIDER: S-EPMC9942956 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature