Multivariate GWAS analysis reveals loci associated with liver functions in continental African populations.

ABSTRACT:

Background

Liver disease is any condition that causes liver damage and inflammation and may likely affect the function of the liver. Vital biochemical screening tools that can be used to evaluate the health of the liver and help diagnose, prevent, monitor, and control the development of liver disease are known as liver function tests (LFT). LFTs are performed to estimate the level of liver biomarkers in the blood. Several factors are associated with differences in concentration levels of LFTs in individuals, such as genetic and environmental factors. The aim of our study was to identify genetic loci associated with liver biomarker levels with a shared genetic basis in continental Africans, using a multivariate genome-wide association study (GWAS) approach.

Methods

We used tw

SUBMITTER: Soremekun C 

PROVIDER: S-EPMC9942994 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature