Untargeted serum metabolomics analysis of Trichinella spiralis-infected mouse.

ABSTRACT:

Background

Trichinellosis, caused by a parasitic nematode of the genus Trichinella, is a zoonosis that affects people worldwide. After ingesting raw meat containing Trichinella spp. larvae, patients show signs of myalgia, headaches, and facial and periorbital edema, and severe cases may die from myocarditis and heart failure. The molecular mechanisms of trichinellosis are unclear, and the sensitivity of the diagnostic methods used for this disease are unsatisfactory. Metabolomics is an excellent tool for studying disease progression and biomarkers; however, it has never been applied to trichinellosis. We aimed to elucidate the impacts of Trichinella infection on the host body and identify potential biomarkers using metabolomics.

Methodology/principal findings

Mice were infec

SUBMITTER: Chienwichai P 

PROVIDER: S-EPMC9943014 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature