Antisense-acting riboswitches: A poorly characterized yet important model of transcriptional regulation in prokaryotic organisms.

ABSTRACT: Riboswitches are RNA elements involved in regulating genes that participate in the biosynthesis or transport of essential metabolites. They are characterized by their ability to recognize their target molecules with high affinity and specificity. Riboswitches are commonly cotranscribed with their target genes and are located at the 5' end of their transcriptional units. To date, only two exceptional cases of riboswitches being situated at the 3' end and transcribing in the antisense direction of their regulated genes have been described. The first case involves a SAM riboswitch located at the 3' end of the ubiG-mccB-mccA operon in Clostridium acetobutylicum involved in converting methionine to cysteine. The second case concerns a Cobalamin riboswitch in Listeria monocytogenes that regulate

SUBMITTER: Serrano-Gutierrez M 

PROVIDER: S-EPMC9943018 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature