Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice.

ABSTRACT: The gut microbiome is thought to play a critical role in the onset and development of psychiatric disorders, including depression and substance use disorder (SUD). To test the hypothesis that the microbiome affects addiction predisposing behaviors and cocaine intravenous self-administration (IVSA) and to identify specific microbes involved in the relationship, we performed 16S rRNA gene sequencing on feces from 228 diversity outbred mice. Twelve open field measures, two light-dark assay measures, one hole board and novelty place preference measure significantly differed between mice that acquired cocaine IVSA (ACQ) and those that failed to acquire IVSA (FACQ). We found that ACQ mice are more active and exploratory and display decreased fear than FACQ mice. The microbial abundances that dif

SUBMITTER: Binh Tran TD 

PROVIDER: S-EPMC9943525 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature