Hypothesis-driven probabilistic modelling enables a principled perspective of genomic compartments.

ABSTRACT: The Hi-C method has revolutionized the study of genome organization, yet interpretation of Hi-C interaction frequency maps remains a major challenge. Genomic compartments are a checkered Hi-C interaction pattern suggested to represent the partitioning of the genome into two self-interacting states associated with active and inactive chromatin. Based on a few elementary mechanistic assumptions, we derive a generative probabilistic model of genomic compartments, called deGeco. Testing our model, we find it can explain observed Hi-C interaction maps in a highly robust manner, allowing accurate inference of interaction probability maps from extremely sparse data without any training of parameters. Taking advantage of the interpretability of the model parameters, we then test hypotheses regardi

SUBMITTER: Kariti H 

PROVIDER: S-EPMC9943678 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature