Factors Affecting Clinical Outcomes Among Patients Infected With HIV and Anal Cancer Treated With Modern Definitive Chemotherapy and Radiation Therapy.

ABSTRACT:

Purpose

Anal cancer affects a disproportionate percentage of persons infected with human immunodeficiency virus (HIV). We analyzed a cohort of patients with HIV and anal cancer who received modern radiation therapy (RT) and concurrent chemotherapy to assess whether certain factors are associated with poor oncologic outcomes.

Patients and methods

We performed a retrospective chart review of 75 consecutive patients with HIV infection and anal cancer who received definitive chemotherapy and RT from 2008 to 2018 at a single academic institution. Local recurrence, overall survival, changes in CD4 counts, and toxicities were investigated.

Results

Most patients were male (92%) with large representation from Black patients (77%). The median pretreatment CD4 count was 280 cell

SUBMITTER: Pfister NT 

PROVIDER: S-EPMC9943777 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature