Duloxetine Exposure During Pregnancy and the Risk of Offspring Being Born Small for Gestational Age or Prematurely: A Nationwide Danish and Swedish Safety Study.

ABSTRACT:

Background

Depression or depressive symptoms are common among pregnant women. The use of antidepressants during pregnancy has grown steadily. The risk of offspring being born small for gestational age or prematurely when exposed to duloxetine during pregnancy is not established.

Objective

We aimed to investigate the association between duloxetine exposure during pregnancy and offspring being born small for gestational age or prematurely.

Methods

We conducted an observational study including live births in Sweden and Denmark (2004-2016). Duloxetine exposure during early (0-140 days) or late (141 to delivery) pregnancy compared with duloxetine-non-exposed, selective serotonin reuptake inhibitor-exposed, venlafaxine-exposed, and duloxetine discontinuers.

Results

I

SUBMITTER: Ankarfeldt MZ 

PROVIDER: S-EPMC9943795 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature