Persistence and Safety of Golimumab in Elderly Patients with Rheumatoid Arthritis and Renal Dysfunction in a Real-World Setting.

ABSTRACT:

Background

The efficacy and safety of golimumab in elderly patients with renal dysfunction are not well evaluated due to the exclusion criteria of clinical trials.

Objective

To assess the persistence and safety of golimumab in elderly rheumatoid arthritis patients with renal dysfunction.

Patients and methods

In this retrospective observational study, we used Japan's nationwide electronic medical records and claims database to identify patients aged 65 years and older who were newly prescribed golimumab for rheumatoid arthritis between July 2011 and June 2018. Patients were divided into three groups according to estimated glomerular filtration rate (eGFR; high, ≥ 90; moderate, ≥ 60, < 90; low, ≥ 30, < 60), and the persistence of golimumab and adverse events were compar

SUBMITTER: Yokoyama S 

PROVIDER: S-EPMC9943813 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature