Industrial Biotechnology Conservation Processes: Similarities with Natural Long-Term Preservation of Biological Organisms.

ABSTRACT: Cryopreservation and lyophilization processes are widely used for conservation purposes in the pharmaceutical, biotechnological, and food industries or in medical transplantation. Such processes deal with extremely low temperatures (e.g., -196 °C) and multiple physical states of water, a universal and essential molecule for many biological lifeforms. This study firstly considers the controlled laboratory/industrial artificial conditions used to favor specific water phase transitions during cellular material cryopreservation and lyophilization under the Swiss progenitor cell transplantation program. Both biotechnological tools are successfully used for the long-term storage of biological samples and products, with reversible quasi-arrest of metabolic activities (e.g., cryogenic storage in l

SUBMITTER: Laurent A 

PROVIDER: S-EPMC9944097 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature