Neural bases for the genesis and CO₂ therapy of periodic Cheyne-Stokes breathing in neonatal male connexin-36 knockout mice.

ABSTRACT: Periodic Cheyne-Stokes breathing (CSB) oscillating between apnea and crescendo-decrescendo hyperpnea is the most common central apnea. Currently, there is no proven therapy for CSB, probably because the fundamental pathophysiological question of how the respiratory center generates this form of breathing instability is still unresolved. Therefore, we aimed to determine the respiratory motor pattern of CSB resulting from the interaction of inspiratory and expiratory oscillators and identify the neural mechanism responsible for breathing regularization induced by the supplemental CO₂ administration. Analysis of the inspiratory and expiratory motor pattern in a transgenic mouse model lacking connexin-36 electrical synapses, the neonatal (P14) Cx36 knockout male mouse, with a persis

SUBMITTER: Casarrubios AM 

PROVIDER: S-EPMC9944137 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature