Olanzapine for the treatment of ICU delirium: a systematic review and meta-analysis.

ABSTRACT:

Background

As an atypical antipsychotic drug, olanzapine is one of the most commonly used drugs for delirium control. There are no systematic evaluations or meta-analyses of the efficacy and safety of olanzapine for delirium control in critically ill adults.

Objectives

In this meta-analysis, we evaluated the efficacy and safety of olanzapine for delirium control in critically ill adults in the intensive care unit (ICU).

Data sources and methods

From inception to October 2022, 12 electronic databases were searched. We retrieved randomized controlled trials (RCTs) and retrospective cohort studies of critically ill adults with delirium that compared the effects of olanzapine and other interventions, including routine care (no intervention), nonpharmaceutical intervention

SUBMITTER: Liu SB 

PROVIDER: S-EPMC9944192 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature