Comparing the transmission potential from sequence and surveillance data of 2009 North American influenza pandemic waves.

ABSTRACT: Technological advancements in phylodynamic modeling coupled with the accessibility of real-time pathogen genetic data are increasingly important for understanding the infectious disease transmission dynamics. In this study, we compare the transmission potentials of North American influenza A(H1N1)pdm09 derived from sequence data to that derived from surveillance data. The impact of the choice of tree-priors, informative epidemiological priors, and evolutionary parameters on the transmission potential estimation is evaluated. North American Influenza A(H1N1)pdm09 hemagglutinin (HA) gene sequences are analyzed using the coalescent and birth-death tree prior models to estimate the basic reproduction number (R ₀ ). Epidemiological priors gathered from published literat

SUBMITTER: Duvvuri VR 

PROVIDER: S-EPMC9944206 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature