Spherical rotary cell seeding system for production of small-caliber tissue-engineered blood vessels with complex geometry.

ABSTRACT: Entirely biological human tissue-engineered blood vessels (TEBV) were previously developed for clinical use. Tissue-engineered models have also proven to be valuable tools in disease modelling. Moreover, there is a need for complex geometry TEBV for study of multifactorial vascular pathologies, such as intracranial aneurysms. The main goal of the work reported in this article was to produce an entirely human branched small-caliber TEBV. The use of a novel spherical rotary cell seeding system allows effective and uniform dynamic cell seeding for a viable in vitro tissue-engineered model. In this report, the design and fabrication of an innovative seeding system with random spherical 360° rotation is described. Custom made seeding chambers are placed inside the system and hold Y-shaped polye

SUBMITTER: Brodeur A 

PROVIDER: S-EPMC9944280 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature